OND logo: Strengthening the power of medical imaging.

Our mission: O.N. Diagnostics is dedicated to improving patient outcomes by developing non-invasive and clinically effective applications that quantitatively exploit the richness of information in CT scans. Our initial focus is in the areas of bone health and orthopaedics.

The science: Based on research developed at UC Berkeley and UC San Francisco, our proprietary and patented approaches combine biomechanical engineering, computational analysis, and medical image processing. We create biomechanically accurate computer models of the patient's bones (with or without bone-implant systems), that are then subjected to a virtual stress test; and in doing so, provide clinicians and researchers with improved, patient-specific assessments of bone strength, fracture risk, and bone-implant stability. Additionally, with our ability to analyze previously-acquired or standard-of-care, pre-operative CT scans, we eliminate the inconvenience, cost, and radiation exposure of a dedicated bone scan.

Collaborators: Our approach has been validated by collaborative studies with some of the top research institutions in the world including, Mayo Clinic, Beth Israel Medical Center and Harvard Medical School, Oregon Health Sciences University, Icelandic Heart Association, the University of Maryland; and with many of the major pharmaceutical companies, including Eli Lilly, Merck, Pfizer, Amgen, and GlaxoSmithKline. Our internal research is partially funded by the National Institutes of Health and Department of Defense.

Products and services: Our flagship product VirtuOst® is the first-ever FDA-cleared, finite-element-based software application that provides patient-specific measures of bone mineral density (BMD), bone strength and load-to-strength ratio at the hip and/or spine. This information can help physicians better assess patient fracture risk, identify osteoporosis and monitor therapy. And unlike DXA (Dual-energy X-ray Absorptiometry), VirtuOst can identify patients with osteopenia (though not yet osteoporosis) who are at high risk of fracture. Additionally, VirtuOst can analyze most standard-of-care clinical CT scans that capture the hip and/or spine – such as spine, pelvis, and abdominal CTs (including CT colonographies and enterographies). The use of a calibration phantom or a particularized acquisition setting is not required.

Publications: Click here for a list of peer-reviewed publications.

Contact Us: For information on how to offer the VirtuOst Bone Strength Assessment to your patients, or how to utilize VirtuOst in your clinical study or research, please contact us at: info@ondiagnostics.com.

© 2014 O.N. Diagnostics, LLC. All rights reserved. VirtuOst is a registered trademark of O.N. Diagnostics, LLC.